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New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27

Constanze Paulus, Oleksandr Gromyko, Andriy Luzhetskyy

A Promiscuous Halogenase for the Derivatization of Flavonoids

Автор: Dominik Kolling , Marc Stierhof , Constanze Lasch , Maksym Myronovskyi, Andriy Luzhetskyy

Halogenation often improves the bioactive properties of natural products and is used in pharmaceutical research for the generation of new potential drug leads. High regio- and stereospecificity, simple reaction conditions and straightforward downstream processing are the main advantages of halogenation using enzymatic biocatalysts compared to chemical synthetic approaches. The identification of new promiscuous halogenases for the modification of various natural products is of great interest in modern drug discovery. In this paper, we report the identification of a new...

New Scabimycins A-C Isolated from Streptomyces acidiscabies (Lu19992)

Paulus C, Zapp J, Luzhetskyy A.

Towards the sustainable discovery and development of new antibiotics

Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, Stadler M, Tormo JR, Genilloud O, Truman AW, Weissman KJ, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch AKH, Loretz B, Lehr CM, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H,...

Bonsecamin: A New Cyclic Pentapeptide Discovered through Heterologous Expression of a Cryptic Gene Cluster

Constanze Lasch, Marc Stierhof, Marta Rodríguez Estévez, Maksym Myronovskyi, Josef Zapp, Andriy Luzhetskyy

Composition of nutrient media and temperature of cultivation imposes effect on the content of secondary metabolites of Nocardiopsis sp. isolated from a Siberian Cave

Axenov-Gribanov DV, Morgunova MM, Vasilieva UA, Gamaiunov SV, Dmitrieva Krasnova ME, Pereliaeva EV, Belyshenko AY, Luzhetskyy AN.

Cyclofaulknamycin with the Rare Amino Acid D-capreomycidine Isolated from a Well-Characterized Streptomyces albus Strain

Liliya Horbal, Marc Stierhof, Anja Palusczak, Nikolas Eckert, Josef Zapp, Andriy Luzhetskyy

Discovery and Heterologous Production of New Cyclic Depsibosamycins

Marc Stierhof, Maksym Myronovskyi, Josef Zapp, Andriy Luzhetskyy

Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2

Lars Gläser, Martin Kuhl, Julian Stegmüller, Christian Rückert, Maksym Myronovskyi, Jörn Kalinowski, Andriy Luzhetskyy, Christoph Wittmann

Engineering the precursor pool to modulate the production of pamamycins in the heterologous host S. albus J1074

Gummerlich N, Manderscheid N, Rebets Y, Myronovskyi M, Gläser L, Kuhl M, Wittmann C, Luzhetskyy A.

Microparticles enhance the formation of seven major classes of natural products in native and metabolically engineered actinobacteria through accelerated morphological development

Kuhl M, Rückert C, Gläser L, Beganovic S, Luzhetskyy A, Kalinowski J, Wittmann C.

Genetically engineered rpsL merodiploidy impacts secondary metabolism and antibiotic resistance in Streptomyces

Oksana Koshla, Maria Lopatniuk, Oksana Borys, Yuya Misaki, Volodymyr Kravets, Iryna Ostash, Anastasiia Shemediuk, Kozo Ochi, Andriy Luzhetskyy, Victor Fedorenko & Bohdan Ostash

Multiple copies of the oxytetracycline gene cluster in selected Streptomyces rimosus strains can provide significantly increased titers

Špela Pikl , Andrés Felipe Carrillo Rincón, Lucija Slemc, Dušan Goranovič, Martina Avbel, Krešimir Gjuračić, Hilda Sucipto, Katja Stare, Špela Baebler, Martin Šala, Meijin Guo, Andriy Luzhetskyy, Hrvoje Petković, Vasilka Magdevska